St. John's Wort (Hypericum perforatum) is one of the most commonly used alternative remedies to treat depression and anxiety. It is believed that the antidepressant properties of St. John's Wort are due to its hypericin content (an antibiotic substance) and other active constituents like flavonoids and hyperforin. While it is not yet clear what the herb's specific active ingredients are, we do know that St. John's Wort increases the production of the neurotransmitter serotonin. In 2005, a study published in the British Medical Journal concluded that St. John's Wort was as effective as prescribed antidepressants. The study also noted that St. John's Wort produced fewer side effects compared to the antidepressants.
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